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[大鼠个体发育过程中脑干和大脑皮质中α₂-和β-肾上腺素能受体数量的变化]

[Changes in the number of alpha 2- and beta-adrenoreceptors in the brain stem and cerebral cortex of rats in ontogeny].

作者信息

Iushkova A A, Dygalo N N

出版信息

Fiziol Zh Im I M Sechenova. 1995 Feb;81(2):7-11.

PMID:7581546
Abstract

Densities of alpha 2- and beta-adrenoceptors were higher in the brain stem of 21-day-old foetuses. The beta-receptors density, however, increased more rapidly in the brain stem after birth. The alpha 2-adrenergic receptors density gradually elevated with ageing in the cortex, the specifics of their ontogenesis being related to regulation of noradrenergic nerve cells function while that of the beta-adrenoceptors reflected a formation of adrenergic synapses in the brain areas in the course of development.

摘要

21日龄胎儿脑干中α2-和β-肾上腺素能受体的密度较高。然而,出生后脑干中β-受体的密度增加得更快。α2-肾上腺素能受体的密度在皮质中随年龄增长而逐渐升高,其个体发生的细节与去甲肾上腺素能神经细胞功能的调节有关,而β-肾上腺素能受体的细节则反映了发育过程中脑区肾上腺素能突触的形成。

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