Blethen S L
Department of Pediatrics, State University of New York at Stony Brook 11794-8111, USA.
Curr Opin Pediatr. 1995 Aug;7(4):466-71. doi: 10.1097/00008480-199508000-00020.
The introduction of human growth hormone (GH) prepared by recombinant DNA technology has resulted in increased numbers of children and adults receiving treatment. This trend has led to questions concerning the safety of GH, particularly when used for indications other than GH deficiency. This review discusses the effects of GH on fluid, lipid, and carbohydrate metabolism; the risk of intracranial hypertension or pseudotumor cerebri; the effects on the skeletal system; the risk of malignancy; and the effects on the immune system. At present, GH treatment appears to be safe, although long-term follow-up of GH-treated patients is necessary.
通过重组DNA技术制备的人生长激素（GH）的引入，使得接受治疗的儿童和成人数量增加。这一趋势引发了关于GH安全性的问题，尤其是当它用于生长激素缺乏症以外的适应症时。本文综述了GH对液体、脂质和碳水化合物代谢的影响；颅内高压或假性脑瘤的风险；对骨骼系统的影响；恶性肿瘤的风险；以及对免疫系统的影响。目前，GH治疗似乎是安全的，尽管对接受GH治疗的患者进行长期随访是必要的。
