Narita T, Matsuda K
Department of Pathology, Mutsu General Hospital, Japan.
Pathol Int. 1995 Jun;45(6):441-7. doi: 10.1111/j.1440-1827.1995.tb03482.x.
A tumor of the right breast was noticed in a 70 year old female. The tumor was round, 1 x 1 cm, and was encapsulated with thin fibrous tissue. The boundary was clear. The cut surface showed a mosaic pattern of brown and white dots and the texture was gritty. Histologically, glandular structures, trabecular or solid epithelial cell nests, myxoid, cartilaginous and osteoid areas, and one ossifying focus were found. Round, polyhedral or fusiform myoepithelial cells proliferated around the glandular structures and were dispersing into the myxoid and cartilaginous tissue. Myoepithelial proliferation was especially marked around the small glandular structure. Immunohistochemically, S-100 protein was strongly positive for the myoepithelial cells around the glandular structures and in the cartilaginous tissue. Until now, 54 cases of pleomorphic adenoma of the breast have been reported. In those cases, the subareolar region was a common site for the tumor, and pleomorphic adenoma was thought to arise from large ducts in this region. No Oriental patients have been reported in the literature.
一名70岁女性被发现右乳有一肿瘤。肿瘤呈圆形，1×1厘米，被薄纤维组织包裹。边界清晰。切面呈棕色和白色斑点的镶嵌图案，质地粗糙。组织学上，发现有腺结构、小梁状或实性上皮细胞巢、黏液样、软骨样和类骨区域，以及一个骨化灶。圆形、多面体或梭形肌上皮细胞在腺结构周围增殖，并散布到黏液样和软骨样组织中。肌上皮增殖在小腺结构周围尤为明显。免疫组化显示，腺结构周围和软骨样组织中的肌上皮细胞S-100蛋白呈强阳性。到目前为止，已报道54例乳腺多形性腺瘤。在这些病例中，乳晕下区域是肿瘤的常见部位，多形性腺瘤被认为起源于该区域的大导管。文献中未报道有东方患者。
