Bellone J, Ghizzoni L, Aimaretti G, Volta C, Boghen M F, Bernasconi S, Ghigo E
Department of Clinical Pathophysiology, University of Turin, Italy.
Eur J Endocrinol. 1995 Oct;133(4):425-9. doi: 10.1530/eje.0.1330425.
Growth hormone-releasing peptide 6 (GHRP-6) is a synthetic hexapeptide with a potent GH-releasing activity after intravenous, subcutaneous, intranasal and oral administration in man. Previous data showed its activity also in some patients with GH deficiency. The aim of our study was to verify the GH-releasing activity of oral GHRP-6 administration on GH secretion in children with normal short stature. The effect of oral GHRP-6 (300 micrograms/kg) was compared with that of the maximally effective dose of intravenous GH-releasing hormone (GHRH-29, 1 microgram/kg). As the GHRH-induced GH rise in children is potentiated by arginine (ARG), even when administered by oral route at low dose (4 g), we studied also the interaction of oral GHRP-6 and ARG administration. We studied 13 children (nine boys and four girls aged 6.2-10.5 years, pubertal stage I) with normal short stature (height less than -2 SD score; height velocity more than -2 SD score; normal bone age; insulin-like growth factor I > 70 micrograms/l). In a first group of children (N = 7), oral GHRP-6 administration induced a GH response (mean +/- SEM; peak at 60 min vs baseline: 18.8 +/- 3.0 vs 1.1 +/- 0.3 micrograms/l, p < 0.0006; area under curve: 1527.3 +/- 263.9 micrograms l-1 h-1) which was similar to that elicited by GHRH (peak at 45 min vs baseline: 20.8 +/- 4.5 vs 2.2 +/- 0.9 micrograms/l, p < 0.007; area under curve: 1429.4 +/- 248.2 micrograms l-1 h-1).(ABSTRACT TRUNCATED AT 250 WORDS)
生长激素释放肽6（GHRP - 6）是一种合成六肽，在人体静脉内、皮下、鼻内和口服给药后具有强大的生长激素释放活性。先前的数据显示其在一些生长激素缺乏患者中也有活性。我们研究的目的是验证口服GHRP - 6对正常身材矮小儿童生长激素分泌的释放活性。将口服GHRP - 6（300微克/千克）的效果与静脉注射生长激素释放激素（GHRH - 29，1微克/千克）的最大有效剂量的效果进行比较。由于精氨酸（ARG）能增强儿童中GHRH诱导的生长激素升高，即使以低剂量（4克）口服给药时也是如此，我们还研究了口服GHRP - 6与ARG给药之间的相互作用。我们研究了13名正常身材矮小的儿童（9名男孩和4名女孩，年龄6.2 - 10.5岁，青春期I期）（身高低于 - 2标准差评分；身高增长速度高于 - 2标准差评分；骨龄正常；胰岛素样生长因子I > 70微克/升）。在第一组儿童（N = 7）中，口服GHRP - 6引起了生长激素反应（平均值±标准误；60分钟时的峰值与基线相比：18.8±3.0对1.1±0.3微克/升，p < 0.0006；曲线下面积：1527.3±263.9微克·升⁻¹·小时⁻¹），这与GHRH引起的反应相似（45分钟时的峰值与基线相比：20.8±4.5对2.2±0.9微克/升，p < 0.007；曲线下面积：1429.4±248.2微克·升⁻¹·小时⁻¹）。（摘要截短于250字）
