Aalkjaer C, Mulvany M J
Department of Pharmacology, University of Aarhus, Denmark.
Blood Press Suppl. 1995;2:113-6.
In this paper the morphological results obtained with isolated subcutaneous resistance arteries from patients with essential hypertension are reviewed. There is good agreement from these studies that the lumen diameter is decreased and the media thickness to lumen diameter ratio increased in patients with essential hypertension, which is consistent with data obtained from in vivo measurements of these variables using plethysmographic methods. On the other hand there is little or no increase in the media thickness. This suggests that an important means by which the morphological changes in hypertension are established is through a reorganization of the wall material around the lumen, a process known as "remodelling"; growth of smooth muscle may only have a minor role. In general, antihypertensive therapy increases the lumen diameter and decreases the media thickness to lumen diameter ratio; recent studies suggest that there may be drug specific effects on these variables.
本文回顾了从原发性高血压患者分离出的皮下阻力动脉所获得的形态学结果。这些研究结果高度一致，即原发性高血压患者的管腔直径减小，中膜厚度与管腔直径之比增加，这与使用体积描记法对这些变量进行体内测量所获得的数据一致。另一方面，中膜厚度几乎没有增加或根本没有增加。这表明，高血压形态学改变确立的一个重要方式是通过管腔周围壁物质的重新组织，这一过程称为“重塑”；平滑肌的生长可能只起次要作用。一般来说，抗高血压治疗会增加管腔直径，并降低中膜厚度与管腔直径之比；最近的研究表明，这些变量可能存在药物特异性效应。
