Foot A B
Bristol Royal Hospital for Sick Children, UK.
Palliat Med. 1995 Jul;9(3):193-9. doi: 10.1177/026921639500900304.
Childhood malignancies differ from those encountered in adult life not only in tumour type but also in their response to treatment. There have been major advances in the use of combined modality and combination chemotherapy regimens over recent years. High-dose therapy with bone marrow and peripheral stem cell transplantation procedures are being increasingly incorporated into specialized treatment regimens, particularly in the management of 'high-risk' and relapsed patients who were previously incurable. Overall, cure rates for children with cancer now exceed 60%. Despite this, the progress in the treatment of some tumour groups remains poor. This paper summarizes recent advances but also highlights some of the problem areas that still exist or are expected to be encountered in the near future.
儿童恶性肿瘤与成人期的恶性肿瘤不同，不仅体现在肿瘤类型上，还体现在对治疗的反应上。近年来，联合治疗和联合化疗方案的应用取得了重大进展。高剂量疗法以及骨髓和外周干细胞移植程序正越来越多地被纳入专门的治疗方案中，尤其是在治疗那些以前无法治愈的“高危”和复发患者时。总体而言，儿童癌症的治愈率目前已超过60%。尽管如此，某些肿瘤组的治疗进展仍然不佳。本文总结了近期的进展，但也突出了一些仍然存在或预计在不久的将来会遇到的问题领域。
