SR 48692促进大鼠胃排空和排便，提示内源性神经降压素的作用。
Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin.
作者信息
Croci T, Giudice A, Manara L, Gully D, Le Fur G
机构信息
SANOFI-Midy S.p.A. Research Center, Milan, Italy.
出版信息
Br J Pharmacol. 1995 Jun;115(3):383-4. doi: 10.1111/j.1476-5381.1995.tb16343.x.
Abstract
We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.
摘要
我们研究了口服非肽类神经降压素受体拮抗剂SR 48692对胃排空和急性排便的影响。SR 48692剂量依赖性地（半数有效剂量约为0.7微克/千克）增加食物悬液的胃排空，但对无热量餐的胃排空没有影响。SR 48692还剂量依赖性地促进排便并增加粪便含水量。我们认为内源性神经降压素的拮抗作用是SR 48692促进胃排空和排便作用的原因。
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