在大鼠运动皮层神经末梢上对磺脲类药物敏感的ATP敏感性钾通道的直接证明。
Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex.
作者信息
Lee K, Dixon A K, Rowe I C, Ashford M L, Richardson P J
机构信息
Department of Pharmacology, University of Cambridge.
出版信息
Br J Pharmacol. 1995 Jun;115(3):385-7. doi: 10.1111/j.1476-5381.1995.tb16344.x.
Abstract
We examined whether ATP-sensitive potassium (KATP) channels are present on presynaptic terminals of the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. A novel fused nerve terminal preparation was developed which produced structures amenable to patch clamp methods. In inside-out recordings a K+ channel was observed which possessed all the major features of the Type 1 KATP channel, including sensitivity to ATP and the antidiabetic sulphonylureas.
摘要
我们研究了大鼠运动皮层（中枢神经系统中磺酰脲结合密度较高的区域）的突触前终末是否存在ATP敏感性钾通道（KATP通道）。我们开发了一种新型的融合神经终末制备方法，该方法产生了适合膜片钳技术的结构。在膜内向外记录中，观察到一种钾通道，它具有1型KATP通道的所有主要特征，包括对ATP和抗糖尿病磺酰脲类药物的敏感性。
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Glucose-regulated potassium channels are sweet news for neurobiologists.葡萄糖调节钾通道对神经生物学家来说是个好消息。
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