P物质诱导的人脑动脉舒张和超极化
Substance P-induced relaxation and hyperpolarization in human cerebral arteries.
作者信息
Petersson J, Zygmunt P M, Brandt L, Högestätt E D
机构信息
Department of Neurology, Malmö General Hospital, Sweden.
出版信息
Br J Pharmacol. 1995 Jul;115(6):889-94. doi: 10.1111/j.1476-5381.1995.tb15893.x.
Abstract
- Vascular effects of substance P were studied in human isolated pial arteries removed from 14 patients undergoing cerebral cortical resection. 2. Substance P induced a concentration-dependent relaxation in the presence of indomethacin. No relaxation was seen in arteries where the endothelium had been removed. 3. N omega-nitro-L-arginine (L-NOARG, 0.3 mM) abolished the relaxation in arteries from six patients. The relaxation was only partially inhibited in the remaining eight patients, the reduction of the maximum relaxation being less than 50% in each patient. 4. The L-NOARG-resistant relaxation was abolished when the external K+ concentration was raised above 30 mM. 5. Substance P caused a smooth muscle hyperpolarization (in the presence of L-NOARG and indomethacin), but only when the artery showed an L-NOARG-resistant relaxation. 6. The results indicate that nitric oxide is an important mediator of endothelium-dependent relaxation in human cerebral arteries. Furthermore, another endothelium-dependent pathway, causing hyperpolarization and vasodilatation, was identified in arteries from more than half the population of patients.
摘要
- 对从14例接受大脑皮质切除术患者身上取下的人离体软脑膜动脉中P物质的血管效应进行了研究。2. 在吲哚美辛存在的情况下，P物质可引起浓度依赖性舒张。在内皮被去除的动脉中未观察到舒张。3. Nω-硝基-L-精氨酸（L-NOARG，0.3 mM）消除了6例患者动脉中的舒张。在其余8例患者中，舒张仅被部分抑制，每位患者最大舒张的降低均小于50%。4. 当细胞外钾离子浓度升高至30 mM以上时，L-NOARG抗性舒张被消除。5. P物质引起平滑肌超极化（在L-NOARG和吲哚美辛存在的情况下），但仅在动脉表现出L-NOARG抗性舒张时出现。6. 结果表明，一氧化氮是人类脑动脉中内皮依赖性舒张的重要介质。此外，在超过半数患者的动脉中发现了另一种导致超极化和血管舒张的内皮依赖性途径。
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