Schröder J, Wenz F, Schad L R, Baudendistel K, Knopp M V
Department of Psychiatry, University of Heidelberg, Germany.
Br J Psychiatry. 1995 Aug;167(2):197-201. doi: 10.1192/bjp.167.2.197.
Neurological soft signs (NSS) such as a disturbed finger-to-thumb opposition are frequently found in schizophrenia. To identify the underlying cerebral changes we investigated sensorimotor cortex and supplementary motor area (SMA) activation during finger-to-thumb opposition using functional magnetic resonance imaging (fMRI).
Ten DSM-III-R schizophrenics and seven healthy controls were included. All subjects were right-handed. fMRI was carried out in a resting condition followed by an activation state (finger-to-thumb opposition) and the activities in the sensorimotor cortices and SMA recorded.
All subjects showed a significant activation of the SMA and both ipsilateral and contralateral sensorimotor cortices. In the controls, ipsilateral finger-to-thumb opposition was associated with a greater left than right hemispheric sensorimotor cortex coactivation. When compared with the healthy controls, the schizophrenic patients showed a decreased activation of both sensorimotor cortices and SMA, as well as a reversed lateralisation effect.
Sensorimotor cortex and SMA dysfunction are associated with motor disturbances in schizophrenia.
诸如手指对拇指对指障碍等神经学软体征在精神分裂症中经常出现。为了确定潜在的大脑变化，我们使用功能磁共振成像（fMRI）研究了在手指对拇指对指过程中感觉运动皮层和辅助运动区（SMA）的激活情况。
纳入了10名DSM-III-R精神分裂症患者和7名健康对照者。所有受试者均为右利手。在静息状态下进行fMRI，随后进入激活状态（手指对拇指对指），并记录感觉运动皮层和SMA中的活动。
所有受试者的SMA以及同侧和对侧感觉运动皮层均出现显著激活。在对照组中，同侧手指对拇指对指与左侧感觉运动皮层比右侧半球有更强的共同激活相关。与健康对照者相比，精神分裂症患者的感觉运动皮层和SMA激活均降低，并且出现了侧化效应逆转。
感觉运动皮层和SMA功能障碍与精神分裂症的运动障碍有关。
