Malla A K, Norman R M, Aguilar O, Carnahan H, Cortese L
Department of Psychiatry, University of Western Ontario, Canada.
Br J Psychiatry. 1995 Aug;167(2):211-5. doi: 10.1192/bjp.167.2.211.
There has been evidence that psychopathology in schizophrenia consists of three separable syndromes: reality distortion, disorganisation, and psychomotor poverty. The objective of this study was to explore the relationship between planning and execution of movement and each of the syndromes in schizophrenia.
Twenty-one right handed DSM-III-R schizophrenic patients performed a total of 80 trials of a motor movement task, varying distance of movement x size of the target x hand. Times taken to plan the movement (RT) and to carry it out (MT) were examined for their relationship with contemporaneous as well as lifetime profiles of the three syndromes in schizophrenia.
Significant correlations are reported between RT and current as well as lifetime measures of disorganisation syndrome. Somewhat weaker correlations are reported between RT and psychomotor poverty, but only for the right-handed tasks. Partial correlations suggest that the influence of neuroleptic medication explains all but one of the correlations between psychomotor poverty and RT, but does not account for the relationship between disorganisation and RT. No other relationship emerged between any of the movement and symptom measures.
These findings indicate that dysfunction in movement planning is related primarily to concurrent disorganisation, as well as to the prominence of disorganisation over the patient's history.
有证据表明，精神分裂症的精神病理学由三种可分离的综合征组成：现实扭曲、紊乱和精神运动迟缓。本研究的目的是探讨精神分裂症患者运动计划与执行以及每种综合征之间的关系。
21名右利手的DSM-III-R精神分裂症患者总共进行了80次运动任务试验，运动距离、目标大小和手的使用情况各不相同。研究了计划运动的时间（反应时间，RT）和执行运动的时间（运动时间，MT）与精神分裂症三种综合征的当前及终生特征之间的关系。
报告了反应时间与紊乱综合征的当前及终生测量值之间存在显著相关性。反应时间与精神运动迟缓之间的相关性较弱，但仅针对右利手任务。偏相关性表明，抗精神病药物的影响解释了精神运动迟缓与反应时间之间除一个相关性之外的所有相关性，但不能解释紊乱与反应时间之间的关系。在任何运动和症状测量指标之间未发现其他关系。
这些发现表明，运动计划功能障碍主要与当前的紊乱有关，也与紊乱在患者病史中的突出程度有关。
