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终止妊娠与精神疾病发病率

Termination of pregnancy and psychiatric morbidity.

作者信息

Gilchrist A C, Hannaford P C, Frank P, Kay C R

机构信息

Department of Child and Adolescent Psychiatry, University of Manchester.

出版信息

Br J Psychiatry. 1995 Aug;167(2):243-8. doi: 10.1192/bjp.167.2.243.

DOI:10.1192/bjp.167.2.243
PMID:7582677
Abstract

BACKGROUND

We investigated whether reported psychiatric morbidity was increased after termination of pregnancy compared with other outcomes of an unplanned pregnancy.

METHOD

This was a prospective cohort study of 13,261 women with an unplanned pregnancy. Psychiatric morbidity reported by GPs after the conclusion of the pregnancy was compared in four groups: women who had a termination of pregnancy (6410), women who did not request a termination (6151), women who were refused a termination (379), and women who changed their minds before the termination was performed (321).

RESULTS

Rates of total reported psychiatric disorder were no higher after termination of pregnancy than after childbirth. Women with a previous history of psychiatric illness were most at risk of disorder after the end of their pregnancy, whatever its outcome. Women without a previous history of psychosis had an apparently lower risk of psychosis after termination than postpartum (relative risk RR = 0.4, 95% confidence interval CI = 0.3-0.7), but rates of psychosis leading to hospital admission were similar. In women with no previous history of psychiatric illness, deliberate self-harm (DSH) was more common in those who had a termination (RR 1.7, 95% CI 1.1-2.6), or who were refused a termination (RR 2.9, 95% CI 1.3-6.3).

CONCLUSIONS

The findings on DSH are probably explicable by confounding variables, such as adverse social factors, associated both with the request for termination and with subsequent self-harm. No overall increase in reported psychiatric morbidity was found.

摘要

背景

我们调查了与意外怀孕的其他结局相比,终止妊娠后报告的精神疾病发病率是否会升高。

方法

这是一项对13261名意外怀孕女性进行的前瞻性队列研究。比较了妊娠结束后全科医生报告的四组女性的精神疾病发病率:终止妊娠的女性(6410名)、未要求终止妊娠的女性(6151名)、被拒绝终止妊娠的女性(379名)以及在终止妊娠前改变主意的女性(321名)。

结果

报告的总精神疾病发病率在终止妊娠后并不高于分娩后。既往有精神疾病史的女性在妊娠结束后无论结局如何,患精神疾病的风险最高。既往无精神病病史的女性在终止妊娠后患精神病的风险明显低于产后(相对风险RR = 0.4,95%置信区间CI = 0.3 - 0.7),但因精神病住院的发病率相似。在既往无精神疾病史的女性中,故意自我伤害(DSH)在终止妊娠的女性(RR 1.7,95% CI 1.1 - 2.6)或被拒绝终止妊娠的女性(RR 2.9,95% CI 1.3 - 6.3)中更为常见。

结论

关于故意自我伤害的研究结果可能可以通过混杂变量来解释,比如与终止妊娠请求以及随后的自我伤害都相关的不良社会因素。未发现报告的精神疾病发病率总体上升。

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