Liubchenko P N, Gorenkov R V, Bendikov E A, Petrakov A V
Med Tr Prom Ekol. 1995(6):4-7.
The examination covered 52 workers engaged into production of linoleum and polyvinylchloride self-sticking coating. The workers were exposed to mixture of chemicals, especially to low concentrations of diethylhexyl phthalate (dioctyl phthalate). Detoxication in the liver was assessed through developed antipyrine test with detection of total and free derivatives of antipyrine in the urine. If compared to other functional tests, the changes in activity of enzymes dependent on cytochrome P-450 were considerably prevalent and marked. Divergent changes were seen--activated enzymes of antipyrine oxidation (I phase of the metabolism) and depression of those participating in the metabolites conjugation. The findings were considered as molecular results of toxic influence on the liver.
该检查涵盖了52名从事油毡和聚氯乙烯自粘涂层生产的工人。这些工人接触化学物质混合物，尤其是低浓度的邻苯二甲酸二乙基己酯（邻苯二甲酸二辛酯）。通过开展安替比林试验，检测尿液中安替比林的总衍生物和游离衍生物，来评估肝脏的解毒功能。与其他功能测试相比，依赖细胞色素P - 450的酶活性变化相当普遍且明显。出现了不同的变化——安替比林氧化酶（代谢的I期）被激活，而参与代谢物结合的酶受到抑制。这些发现被认为是对肝脏有毒性影响的分子结果。
