[Evaluation of the functional status of hepatic microsomal enzymes in workers exposed to carbon dioxide and vinyl chloride by using the antipyrine test].

Examined were 42 CS2-exposed subjects, 34 CV-exposed subjects and 14 healthy people (control group) with no exposure to chemicals that might change the hepatic microsomal enzymes activity. All the subjects underwent antipyrine test (clearance and plasma half-time). The activities of AspAT and AlAT aminotransferases, alkaline phosphatase, gamma-glutamyl-transferase, and the value of thymol test and BSP were determined. Furthermore, in CV-exposed subjects, the organic clearance for N 2,4-dimethyl-acetanilide-iminodiacetic acid was determined. It was demonstrated that the mean value of antipyrine clearance was significantly reduced in CS2-exposed group, whereas in CV-exposed subjects the mean clearance value differed significantly from the control group value. The pathological values of antipyrine clearance were found in 12 CS2-exposed and only in 3 CV-exposed subjects. Pathological findings of the Hepida test were found in 3 CV-exposed subjects who exhibited normal antipyrine clearance values. This would imply that the Hepida test detects disturbances of different type in hepatic cells functioning, as compared to the antipyrine test. The studies confirmed that the antipyrine test performed in a simplified version (a single biological sampling) bears the same reference value for the detection of disturbances in hepatic microsomal enzymes as the traditional version of the test calling for repeated collection of blood or saliva.