Cuparencu B, Horák J
Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Res Commun Mol Pathol Pharmacol. 1995 Jul;89(1):57-66.
In rats rendered hyperlipidemic by the interperitoneal injection of Triton WR-1339, the administration of 4'-chlorodiazepam, a selective agonist of the peripheral type of benzodiazepine (BZO) receptors evoked significant reductions of serum lipids. PK 11195, a specific antagonist of these receptors, partially inhibited these effects. Flumazenil, a selective antagonist of the central BZD receptors, enhanced the lipid lowering activity of 4'-chlorodiazepam.
通过腹腔注射Triton WR - 1339使大鼠产生高脂血症后，给予外周型苯二氮䓬（BZO）受体的选择性激动剂4'-氯地西泮可显著降低血脂。这些受体的特异性拮抗剂PK 11195可部分抑制这些作用。中枢BZD受体的选择性拮抗剂氟马西尼可增强4'-氯地西泮的降脂活性。
