• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

佐匹克隆对高脂血症大鼠血糖水平和血脂的急性影响。与PK 11195和氟马西尼的相互作用。

Acute effects of zopiclone on blood glucose level and serum lipids in hyperlipidemic rats. Interactions with PK 11195 and flumazenil.

作者信息

Horák J, Cuparencu B, Horák A

机构信息

Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Oradea, Cluj-Napoca, Romania.

出版信息

Acta Physiol Hung. 2000;87(2):185-92.

PMID:11205967
Abstract

UNLABELLED

Intraperitoneal administration of 5 mg/kg zopiclone a cyclopyrolone acting on the central benzodiazepine receptors was found to produce significant reduction of total lipids, total cholesterol and triglyceride in rats randered hyperlipidemic by intraperitoneal injection of Triton W-1339. Blood glucose level was also reduced. Flumazenil (10 mg/kg) potentiated the hypoglicemic effect of zopiclone but had no additional effect on serum lipids. PK 11195 (25 mg/kg) antagonized the hypolipidemic effects of zopiclone.

IN CONCLUSION

  1. The central benzodiazepine receptors are not involved in the hypolipidemic activity of zopiclone. 2. The peripheral type benzodiazepine receptors are partly responsible, for the hypolipidemic activity of this cyclopirrolone. 3. The changes of blood glucose level induced by these drugs does not seem to be related to benzodiazepine receptors.
摘要

未标记

腹腔注射5毫克/千克佐匹克隆（一种作用于中枢苯二氮䓬受体的环吡咯酮），可使腹腔注射Triton W - 1339致高脂血症的大鼠的总脂质、总胆固醇和甘油三酯显著降低。血糖水平也降低。氟马西尼（10毫克/千克）增强了佐匹克隆的降血糖作用，但对血清脂质无额外影响。PK 11195（25毫克/千克）拮抗了佐匹克隆的降血脂作用。

结论

  1. 中枢苯二氮䓬受体不参与佐匹克隆的降血脂活性。2. 外周型苯二氮䓬受体部分负责这种环吡咯酮的降血脂活性。3. 这些药物引起的血糖水平变化似乎与苯二氮䓬受体无关。

相似文献

1
Acute effects of zopiclone on blood glucose level and serum lipids in hyperlipidemic rats. Interactions with PK 11195 and flumazenil.佐匹克隆对高脂血症大鼠血糖水平和血脂的急性影响。与PK 11195和氟马西尼的相互作用。
Acta Physiol Hung. 2000;87(2):185-92.
2
Acute effects of zopiclone on blood glucose level and serum lipids in hyperlipidemic rats.佐匹克隆对高脂血症大鼠血糖水平和血脂的急性影响。
Acta Physiol Hung. 2000;87(2):193-9.
3
Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil.4'-氯地西泮对高脂血症大鼠血糖和血脂的影响：与PK 11195和氟马西尼的相互作用
Res Commun Mol Pathol Pharmacol. 1995 Jul;89(1):57-66.
4
Effects of midazolam on glycemia and serum lipids in rats.咪达唑仑对大鼠血糖和血脂的影响。
Acta Physiol Hung. 1996;84(4):389-98.
5
Effects of zopiclone on blood glucose level, serum lipid concentration and clot lysis time in normoglycemic and normolipidemic rats.佐匹克隆对血糖正常和血脂正常大鼠血糖水平、血脂浓度及凝血块溶解时间的影响。
Acta Physiol Hung. 2001;88(2):139-44. doi: 10.1556/APhysiol.88.2001.2.6.
6
Zopiclone potentiates the antinociceptive effect of morphine in rats.佐匹克隆可增强吗啡对大鼠的镇痛作用。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):526-9. doi: 10.1007/BF00169309.
7
Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.佐匹克隆对恒河猴的立体选择性辨别刺激效应。
Psychopharmacology (Berl). 2003 Jan;165(3):222-8. doi: 10.1007/s00213-002-1286-9. Epub 2002 Nov 14.
8
Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone.
Naunyn Schmiedebergs Arch Pharmacol. 1987 May;335(5):547-50. doi: 10.1007/BF00169122.
9
Effects of acute intraperitoneal administration of tetrazepam on blood glucose level and serum lipids in hyperlipidemic albino rats.腹腔注射替马西泮对高脂血症白化大鼠血糖水平和血脂的急性影响。
Acta Physiol Hung. 1997;85(4):353-8.
10
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Pharmacol Biochem Behav. 1999 Nov;64(3):611-23. doi: 10.1016/s0091-3057(99)00125-2.