Nakahara T, Ishii K, Iwamoto K, Nakayama K
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Res Commun Mol Pathol Pharmacol. 1995 Jul;89(1):77-84.
The nitric oxide synthase inhibitor, NG-nitro-L-arginine, suppressed hypotensive response to acetylcholine, but not to histamine, in pentobarbital-anesthetized dogs. Infusions of acetylcholine increased plasma cyclic GMP levels, while histamine infusions did not. These results indicate that there is an apparent difference in the contributions of nitric oxide to the hypotensive mechanisms of acetylcholine and histamine.
在戊巴比妥麻醉的犬中，一氧化氮合酶抑制剂NG-硝基-L-精氨酸可抑制对乙酰胆碱的降压反应，但对组胺引起的降压反应无抑制作用。输注乙酰胆碱可使血浆环鸟苷酸水平升高，而输注组胺则不会。这些结果表明，一氧化氮对乙酰胆碱和组胺降压机制的贡献存在明显差异。
