Black D W, Goldstein R B, Noyes R, Blum N
Department of Psychiatry, University of Iowa, College of Medicine, Iowa City 52242, USA.
Psychiatr Genet. 1995 Spring;5(1):37-41. doi: 10.1097/00041444-199521000-00006.
The authors report findings from a blind, controlled study of obsessive-compulsive disorder (OCD). Prevalence rates of generalized anxiety disorder (GAD) and major depressive disorder (MDD) were compared among first-degree relatives of probands with OCD and co-morbid GAD or MDD, respectively. Rates of MDD were not increased in relatives of probands with OCD and MDD; neither were rates of GAD increased in relatives of probands with OCD and GAD, although rates of GAD were increased among relatives of probands with OCD compared to relatives of healthy controls. The authors explore the implications of the findings.
作者报告了一项关于强迫症（OCD）的盲法对照研究结果。分别比较了患有强迫症合并广泛性焦虑症（GAD）或重度抑郁症（MDD）的先证者一级亲属中广泛性焦虑症和重度抑郁症的患病率。患有强迫症和重度抑郁症的先证者亲属中重度抑郁症的患病率并未增加；患有强迫症和广泛性焦虑症的先证者亲属中广泛性焦虑症的患病率也未增加，不过与健康对照者的亲属相比，患有强迫症的先证者亲属中广泛性焦虑症的患病率有所增加。作者探讨了这些研究结果的意义。
