New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity.

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作者信息

De Nanteuil G, Gloanec P, Lila C, Portevin B, Boudon A, Rupin A, Verbeuren T J

机构信息

Division of Medicinal Chemistry, Institut de Recherche Servier, Suresnes, France.

出版信息

Bioorg Med Chem. 1995 Aug;3(8):1019-24. doi: 10.1016/0968-0896(95)00107-r.

DOI:10.1016/0968-0896(95)00107-r

PMID:7582976

Abstract

Structural variations of P2 and P3 residues in tripeptidic boroarginine thrombin inhibitors led to compounds with similar potency than reference compound DuP 714, but with enhanced selectivity for thrombin compared to plasmin.

摘要

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