1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors.
作者信息
Harmat N J, Di Bugno C, Criscuoli M, Giorgi R, Lippi A, Martinelli A, Monti S, Subissi A
机构信息
Menarini Ricerche S.p.A. Laboratori di Firenze, Italy.
出版信息
Bioorg Med Chem Lett. 1998 May 19;8(10):1249-54. doi: 10.1016/s0960-894x(98)00200-5.
PMID:9871744
Abstract
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
摘要
Zotero 插件