Sandford A J, Moffatt M F, Daniels S E, Nakamura Y, Lathrop G M, Hopkin J M, Cookson W O
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
Eur J Hum Genet. 1995;3(3):188-94. doi: 10.1159/000472294.
Atopy is a common and genetically heterogeneous syndrome predisposing to allergic asthma and rhinitis. A locus linked to the atopy phenotype has been shown to be present on chromosome 11q12-13. Linkage has only been seen in maternally derived alleles. We have constructed a genetic linkage map of the region, using 15 markers to span approximately 27 cM, and integrate previously published maps. Under a model of maternal inheritance, the atopy locus is placed within a 7-cM interval between D11S480 and D11S451. The interval contains the important candidate gene FCERIB.
特应性是一种常见的、具有遗传异质性的综合征，易导致过敏性哮喘和鼻炎。已证明与特应性表型相关的一个基因座位于11号染色体的11q12 - 13区域。连锁仅在母系遗传的等位基因中出现。我们构建了该区域的遗传连锁图谱，使用15个标记跨越约27厘摩，并整合了先前发表的图谱。在母系遗传模型下，特应性基因座位于D11S480和D11S451之间7厘摩的区间内。该区间包含重要的候选基因FCERIB。
