Bernards R
Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam.
Curr Biol. 1995 Aug 1;5(8):859-61. doi: 10.1016/s0960-9822(95)00173-4.
When certain cells differentiate, Myc in Myc-Max heterodimers is replaced by Mad or Mxi, generating heterodimers that suppress transcription by interacting with the repressor Sin3.
当某些细胞分化时,Myc-Max异源二聚体中的Myc会被Mad或Mxi取代,从而产生通过与阻遏物Sin3相互作用来抑制转录的异源二聚体。