O'Brodovich H M
Department of Paediatrics, University of Toronto, ON, Canada.
New Horiz. 1995 May;3(2):240-7.
Clinical and laboratory-based studies of pulmonary edema have usually focused on the mechanisms responsible for the production of the edema and how therapeutic maneuvers can oppose or treat such processes. Recently, there has been increasing interest in the mechanisms involved in the clearance of airspace fluids. These studies have demonstrated that active transport of Na+ by the distal lung epithelium plays an important physiologic role in the clearance of pulmonary edema fluid. Specifically, the ability of the lung to clear its fluid by active transport processes correlates with survival from high-pressure or high-permeability pulmonary edema. Also, studies have shown that immaturity of Na+ transport processes and, specifically, inadequate expression of Na+ channels contribute to the pathogenesis of respiratory distress syndrome in the newborn.
肺水肿的临床和基于实验室的研究通常集中在导致水肿产生的机制以及治疗措施如何对抗或治疗这些过程。最近，人们对肺泡腔液体清除所涉及的机制越来越感兴趣。这些研究表明，远端肺上皮细胞对Na+的主动转运在肺水肿液的清除中起着重要的生理作用。具体而言，肺通过主动转运过程清除其液体的能力与高压或高通透性肺水肿后的生存率相关。此外，研究表明，Na+转运过程的不成熟，特别是Na+通道表达不足，是新生儿呼吸窘迫综合征发病机制的一个因素。
