硝基-L-精氨酸增加脑缺血诱导的脑脊液中内皮素-1的含量。
Nitro-L-arginine augments the endothelin-1 content of cerebrospinal fluid induced by cerebral ischemia.
作者信息
Spatz M, Stanimirovic D, Strasser A, McCarron R M
机构信息
National Institutes of Health, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
出版信息
Brain Res. 1995 Jun 26;684(1):99-102. doi: 10.1016/0006-8993(95)00438-v.
The effect of nitro-L-arginine (NLA), inhibitor of NO synthase, on ET-1 content in cerebrospinal fluid (CSF) and on the vascular system was investigated in global ischemia/reperfusion of Mongolian gerbils. The results indicate that NLA induced a prolonged (2-3-fold) increase of ET-1 concentration above that seen in the CSF of untreated animals during ischemia/reperfusion. Both the transient and prolonged rise of ET-1 content observed in the CSF coincided with the reduction in the cerebral blood flow seen in untreated and NLA-treated gerbils, respectively, at the time of reperfusion.
在蒙古沙鼠全脑缺血/再灌注模型中，研究了一氧化氮合酶抑制剂硝基-L-精氨酸（NLA）对脑脊液（CSF）中内皮素-1（ET-1）含量及血管系统的影响。结果表明，在缺血/再灌注期间，NLA使ET-1浓度比未处理动物脑脊液中的浓度延长升高（2至3倍）。在再灌注时，未处理和NLA处理的沙鼠脑脊液中观察到的ET-1含量的短暂和持续升高分别与脑血流量的减少相一致。
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