橄榄体脑桥小脑萎缩和Shy-Drager综合征患者小脑中小脑素和促肾上腺皮质激素释放激素的减少。

Decrease in cerebellin and corticotropin-releasing hormone in the cerebellum of olivopontocerebellar atrophy and Shy-Drager syndrome.

作者信息

Mizuno Y, Takahashi K, Totsune K, Ohneda M, Konno H, Murakami O, Satoh F, Sone M, Takase S, Itoyama Y

机构信息

Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Brain Res. 1995 Jul 17;686(1):115-8. doi: 10.1016/0006-8993(95)00467-5.

DOI:10.1016/0006-8993(95)00467-5

PMID:7583264

Abstract

Four neuropeptides; cerebellin, corticotropin-releasing hormone (CRH), neuropeptide Y and somatostatin were studied by radioimmunoassay in the postmortem human brains obtained from three patients with olivopontocerebellar atrophy (OPCA) and one with Shy-Drager syndrome. Significant decreases in cerebellin and CRH concentrations were found in the cerebellar hemisphere of these diseases compared with controls. These findings suggest important pathophysiological roles of cerebellin and CRH in these cerebellar diseases. Such significant decreases were not found in neuropeptide Y and somatostatin.

摘要

采用放射免疫分析法，对取自3例橄榄体脑桥小脑萎缩（OPCA）患者和1例Shy-Drager综合征患者的死后人类大脑进行了研究，检测了四种神经肽，即小脑素、促肾上腺皮质激素释放激素（CRH）、神经肽Y和生长抑素。与对照组相比，这些疾病患者小脑半球中的小脑素和CRH浓度显著降低。这些发现表明小脑素和CRH在这些小脑疾病中具有重要的病理生理作用。而神经肽Y和生长抑素未发现如此显著的降低。