Kish S J, Robitaille Y, el-Awar M, Schut L, DiStefano L, Ball M J, Mazurek M F
Human Neurochemical Pathology Laboratory, Clarke Institute of Psychiatry, Toronto, Canada.
J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):1013-5. doi: 10.1136/jnnp.56.9.1013.
Somatostatin-like immunoreactivity (SLI) was measured in the brains of nine patients with dominantly inherited olivopontocerebellar atrophy (OPCA), who all had a marked deficit of the cholinergic marker choline-acetyltransferase (ChAT) in the cerebral cortex and striatum. Mean concentrations of SLI in OPCA were significantly reduced by 42-58% in parietal and occipital cortices and frontal cortical eye fields, but were normal in other cortical areas, including two subdivisions of the temporal cortex which show marked depletions of both SLI and ChAT in Alzheimer's disease. This dissociation of SLI and ChAT indicates that a cortical cholinergic deficit does not invariably lead to reduction of somatostatin. In the caudate nucleus, the region of OPCA brain having the most severe ChAT deficit (-81%), SLI levels were significantly elevated by 46% and were negatively and significantly correlated with ChAT activities (r = -0.66). The SLI alterations could be due to abnormal somatostatin metabolism or release, or an increased number of somatostatin-containing neurons and could contribute to the brain dysfunction of OPCA.
在9例常染色体显性遗传性橄榄体脑桥小脑萎缩（OPCA）患者的大脑中检测了生长抑素样免疫反应性（SLI），这些患者在大脑皮质和纹状体中均有明显的胆碱能标志物胆碱乙酰转移酶（ChAT）缺乏。OPCA患者顶叶和枕叶皮质以及额叶皮质眼区的SLI平均浓度显著降低了42%-58%，但在其他皮质区域正常，包括颞叶皮质的两个亚区，这两个亚区在阿尔茨海默病中显示SLI和ChAT均明显减少。SLI和ChAT的这种分离表明，皮质胆碱能缺乏并不总是导致生长抑素减少。在尾状核中，OPCA患者大脑中ChAT缺乏最严重的区域（-81%），SLI水平显著升高了46%，并且与ChAT活性呈显著负相关（r = -0.66）。SLI的改变可能是由于生长抑素代谢或释放异常，或者是含生长抑素神经元数量增加，并且可能导致OPCA的脑功能障碍。
