Jalenques I, Albuisson E, Despres G, Romand R
Laboratoire de neurobiologie et Physiologie du développement, Université Blaise Pascal-Clermont II, Aubière, France.
Brain Res. 1995 Jul 24;686(2):223-32. doi: 10.1016/0006-8993(95)00463-z.
The age-related change in glial fibrillary acidic protein (GFAP) immunoreactivity was analyzed in young (3 months) and old (24 months) adult rat cochlear nuclei (CN). Quantitative analyses show a significant increase with age, in the number of GFAP positive astrocytes and processes in the old adult when compared with the young adult rat. There was also a differential distribution of GFAP immunoreactivity in the young adult CN where it predominates in the granular cell region, whereas in old rats, the GFAP immunoreactivity distribution was homogeneous in all parts of the nucleus. There was no change in the total number of neurons between these two stages in any part of the nucleus except for the antero-ventral CN, where a decrease in neuronal number was observed in the aged rats. The increase in GFAP immunoreactivity was related to an increase of both GFAP positive astrocyte number and processes. The increase of GFAP positive astrocytes may be due either to an alteration of auditory nerve fibers, changing the trophic interactions with post-synaptic cells, or to intrinsic alterations of CN neurons and local circuits reflecting aging of the CN.
分析了年轻（3个月）和老年（24个月）成年大鼠耳蜗核（CN）中胶质纤维酸性蛋白（GFAP）免疫反应性的年龄相关变化。定量分析表明，与年轻成年大鼠相比，老年成年大鼠中GFAP阳性星形胶质细胞和突起的数量随年龄显著增加。在年轻成年CN中，GFAP免疫反应性也存在差异分布，其在颗粒细胞区域占主导地位，而在老年大鼠中，GFAP免疫反应性在核的所有部分分布均匀。除了前腹侧CN外，在这两个阶段核的任何部分神经元总数均无变化，在前腹侧CN中，老年大鼠的神经元数量减少。GFAP免疫反应性的增加与GFAP阳性星形胶质细胞数量和突起的增加有关。GFAP阳性星形胶质细胞的增加可能是由于听神经纤维的改变，改变了与突触后细胞的营养相互作用，或者是由于CN神经元和反映CN衰老的局部回路的内在改变。
