Fairshter R D, Novey H S, Marchioli L E, Wilson A F
J Allergy Clin Immunol. 1979 Jan;63(1):39-46. doi: 10.1016/0091-6749(79)90160-x.
Pulmonary function results were compared in 15 allergic rhinitis and 30 normal subjects. Airways resistance (RAW) was higher (p less than 0.01) and specific conductance (SGAW) and lower (p less than 0.01) in the rhinitis group. Maximal expiratory flow (VeMax), lung volumes, and results of tests measuring airways closure, distribution of ventilation, diffusing capacity, volume of isoflow, and density-dependence of VeMax at 50% of vital capacity (deltaVeMax50) did not differ significantly between the two groups. Following inhalation of isoproterenol, RAW decreased and SGAW and VeMax increased significantly in both groups. On the other hand, delta-VeMax50 decreased significantly in the rhinitis group (p less than 0.01) and increased significantly in the control group (p less than 0.05). In addition to comparing pulmonary function in rhinitis patients and control subjects, physiologic measurements were also made on two separate occasions in the rhinitis subjects (minimal or no symptoms; very symptomatic). Although rhinitis symptomatology varied considerably (p less than 0.001), pulmonary function results were not significantly different. Hence we conclude that: (1) Rhinitis subjects have large airway constriction which does not vary with season or symptoms. (2) As in normal control subjects, airflow limitation occurs in the large airways of rhinitis subjects. (3) The predominant site of isoproterenol-associated bronchodilatation differs between allergic rhinitis and normal subjects.
对15名变应性鼻炎患者和30名正常受试者的肺功能结果进行了比较。鼻炎组的气道阻力（RAW）较高（p<0.01），比气道传导率（SGAW）较低（p<0.01）。两组之间的最大呼气流量（VeMax）、肺容量以及气道闭合、通气分布、弥散能力、等流量容积和肺活量50%时VeMax的密度依赖性（deltaVeMax50）测试结果无显著差异。吸入异丙肾上腺素后，两组的RAW均降低，SGAW和VeMax均显著增加。另一方面，鼻炎组的delta-VeMax50显著降低（p<0.01），而对照组则显著增加（p<0.05）。除了比较鼻炎患者和对照受试者的肺功能外，还对鼻炎受试者在两个不同时间（症状轻微或无症状；症状非常明显）进行了生理测量。尽管鼻炎症状差异很大（p<0.001），但肺功能结果无显著差异。因此，我们得出以下结论：（1）鼻炎受试者存在大气道收缩，且不随季节或症状变化。（2）与正常对照受试者一样，鼻炎受试者的大气道也存在气流受限。（3）变应性鼻炎患者和正常受试者中，异丙肾上腺素相关支气管扩张的主要部位不同。
