Lidington R E, Cotton D J, Graham B L, Dosman J A
Ann Allergy. 1979 Jan;42(1):28-33.
Nine young lifetime nonsmoking patients with symptoms of rhinitis but without any history of asthma or wheezing and nine age-matched healthy lifetime nonsmoking control subjects were studied with respect to subdivisions of lung volume, forced vital capacity, forced expiratory volume (1.0 sec), and flow-volume curves breathing air, and also breathing a mixture of 80% helium--20% oxygen (He-O2) from which were obtained airflows at 50% VC (Vmax50), the percentage increase in Vmax50 breathing He-O2 as compared to air (deltaVmax50) and the point where He-O2 and airflow-volume curves became identical (Visov). No significant differences between the two groups in age, subdivisions of lung volume or forced expiratory airflow rates were recorded. However, deltaVmax50 was significantly lower in the patients (16.4 +/- 12.0) compared to the controls (47.7 +/- 16.4) (p less than .001) and Visov was higher in the patients (28.4 +/- 14.9) as compared to the controls (14.4 +/- 7.6) (p less than .01). After bronchodilator therapy Vmax50 increased in the control subjects (p less than .005) but not in the patients and deltaVmax 50 decreased in the control group but was unchanged in the rhinitis patients. These results suggest that patients with rhinitis who have normal airflow rates may have peripheral airways obstruction not readily reversible with bronchodilators.
对9名有鼻炎症状但无哮喘或喘息病史的年轻终生不吸烟患者以及9名年龄匹配的健康终生不吸烟对照受试者进行了研究，内容包括肺容积细分、用力肺活量、用力呼气量（1.0秒）以及呼吸空气和呼吸80%氦气-20%氧气混合气体时的流量-容积曲线，从中获取50%肺活量时的气流（Vmax50）、呼吸氦氧混合气时Vmax50相对于空气的增加百分比（δVmax50）以及氦氧混合气和气流-容积曲线变得相同的点（Visov）。两组在年龄、肺容积细分或用力呼气气流速率方面无显著差异。然而，与对照组（47.7±16.4）相比，患者的δVmax50显著更低（16.4±12.0）（p<0.001），且与对照组（14.4±7.6）相比，患者的Visov更高（28.4±14.9）（p<0.01）。支气管扩张剂治疗后，对照组的Vmax50增加（p<0.005），但患者组未增加，对照组的δVmax50降低，但鼻炎患者组无变化。这些结果表明，气流速率正常的鼻炎患者可能存在外周气道阻塞，支气管扩张剂不易使其逆转。
