Crago S S, Mestecky J
Cell Immunol. 1984 Jun;86(1):222-9. doi: 10.1016/0008-8749(84)90374-5.
The ability of colostral lymphocytes to respond to pokeweed mitogen, phytohemagglutinin, or Epstein-Barr virus was examined. None of these mitogens induced colostral cells to differentiate into immunoglobulin-containing cells, either in the absence or in the presence of mitomycin C-treated mononuclear cells or T-cell-enriched populations from peripheral blood. Cocultivation of mononuclear cells from the peripheral blood of normal adults with mitomycin C-treated colostral cells resulted in a marked suppression of the generation of immunoglobulin-containing cells in response to pokeweed mitogen. The inhibitory effect was seen in peripheral blood mononuclear cell:colostral cell ratios of 1:1, 5:1, and 10:1. However, colostral cells had little effect on the ability of peripheral blood lymphocytes to proliferate in response to phytohemagglutinin or to allogeneic stimulation.
研究了初乳淋巴细胞对商陆有丝分裂原、植物血凝素或爱泼斯坦-巴尔病毒的反应能力。在不存在或存在丝裂霉素C处理的单核细胞或外周血中富含T细胞的群体的情况下，这些有丝分裂原均未诱导初乳细胞分化为含免疫球蛋白的细胞。正常成年人外周血单核细胞与丝裂霉素C处理的初乳细胞共培养，导致对商陆有丝分裂原反应的含免疫球蛋白细胞的生成受到明显抑制。在外周血单核细胞与初乳细胞的比例为1:1、5:1和10:1时均可见到抑制作用。然而，初乳细胞对外周血淋巴细胞因植物血凝素或同种异体刺激而增殖的能力影响很小。
