Pickoff A S, Zies L, Ferrer P L, Tamer D, Wolff G, Garcia O, Gelband H
J Pediatr. 1979 Jan;94(1):144-6. doi: 10.1016/s0022-3476(79)80381-9.
Five patients, age 3 weeks to 11 years, presented with supraventricular tachycardia that remained uncontrolled following adequate digitalization. Four of these patients underwent invasive electrophysiologic studies to determine the mechanism of the arrhythmias. Of these four patients, three had concealed Wolff-Parkinson-White syndrome, and one patient had evidence of dual A-V nodal pathways. Propranolol was added to the medical treatment and was administered orally in doses ranging from 7 to 14 mg/kg/day (average 9 mg/kg/day). All five children remain free of their tachycardia except for one patient who occasionally has supraventricular tachycardia with febrile illnesses. No adverse reactions to these high doses of propranolol were encountered.
5例年龄在3周至11岁的患者，表现为室上性心动过速，在充分洋地黄化后仍未得到控制。其中4例患者接受了有创电生理检查以确定心律失常的机制。在这4例患者中，3例有隐匿性预激综合征，1例有双房室结径路的证据。普萘洛尔被添加到药物治疗中，口服剂量为7至14mg/kg/天（平均9mg/kg/天）。除1例患者在发热性疾病时偶尔出现室上性心动过速外，所有5名儿童均未再出现心动过速。未发现对这些高剂量普萘洛尔有不良反应。
