Teuscher A, Bossi E, Imhof P, Erb E, Stocker F P, Weber J W
Am J Cardiol. 1978 Aug;42(2):304-7. doi: 10.1016/0002-9149(78)90916-5.
Propranolol was administered during the last 20 days of pregnancy to a diabetic woman because of fetal tachycardia (heart rate approximately 200 beats/min). With a daily dose of 160 mg of propranolol, a fetal heart rat of 120 to 160 beats/min could be achieved. Blood concentration of propranolol was measured in the mother and infant after birth. The level in the neonatal blood was 20 percent of the maternal sample, which is definitely higher than expected from animal experiments. No undersirable effect of propranolol treatment was detected. Postpartum, the infant demonstrated paroxysmal supraventricular tachycardia, and propranolol was again essential in maintaining a normal rate.
由于胎儿心动过速（心率约为200次/分钟），在妊娠的最后20天给一名糖尿病妇女使用了普萘洛尔。每日剂量为160毫克普萘洛尔时，可使胎儿心率达到120至160次/分钟。出生后测定了母亲和婴儿体内普萘洛尔的血药浓度。新生儿血液中的水平为母亲样本的20%，这肯定高于动物实验的预期。未检测到普萘洛尔治疗的不良影响。产后，婴儿出现阵发性室上性心动过速，普萘洛尔对维持正常心率再次至关重要。
