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小肠肿瘤

Small bowel tumors.

作者信息

Basson M D

机构信息

Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA.

出版信息

Curr Opin Gen Surg. 1993:219-24.

PMID:7583974
Abstract

Small bowel tumors include adenocarcinomas, carcinoids, lymphomas, and sarcomas, as well as a variety of benign polyps, which should be excised to rule out malignancy. Although small bowel tumors are traditionally difficult to diagnose, a heightened index of suspicion should be combined with improved diagnostic techniques to increase yield and decrease delays in identification. The management of bioactive carcinoid tumors has rapidly advanced over the past year. Increasing experience with the stable somatostatin analogue octreotide has enabled regulation of hormonal secretion by these tumors both chronically and during acute "carcinoid crisis." In addition, early identification may be facilitated by the use of isotopically labeled variants of the compound. Although the development of sophisticated pharmacotherapeutic probes has improved the management of secretory small intestinal tumors, the prognosis for adenocarcinomas, lymphomas, and sarcomas still primarily reflects on the time of delay in diagnosis and awaits an improved understanding of the pathobiology of these malignant lesions.

摘要

小肠肿瘤包括腺癌、类癌、淋巴瘤和肉瘤,以及各种良性息肉,应将其切除以排除恶性肿瘤。尽管传统上小肠肿瘤难以诊断,但提高的怀疑指数应与改进的诊断技术相结合,以提高检出率并减少识别延迟。在过去一年中,生物活性类癌肿瘤的治疗取得了迅速进展。对稳定的生长抑素类似物奥曲肽的经验不断增加,使得能够长期以及在急性“类癌危象”期间调节这些肿瘤的激素分泌。此外,使用该化合物的同位素标记变体可能有助于早期识别。尽管先进的药物治疗探针的开发改善了分泌性小肠肿瘤的治疗,但腺癌、淋巴瘤和肉瘤的预后仍主要取决于诊断延迟的时间,并且有待对这些恶性病变的病理生物学有更好的了解。

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