Fahnestock M L, Johnson J L, Feldman R M, Neveu J M, Lane W S, Bjorkman P J
Division of Biology, California Institute of Technology, Pasadena 91125, USA.
Immunity. 1995 Nov;3(5):583-90. doi: 10.1016/1074-7613(95)90129-9.
The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.
