Bergeman E R, Graves M, Lawrence C B
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Proc Int Conf Intell Syst Mol Biol. 1995;3:48-56.
Genomics is becoming a data-intensive science, and an increasing number of laboratories are generating data which swamps storage in traditional paper-and-ink notebooks. Capturing the data flow requires large systems with multiple applications manipulating the same or similar data. Large systems often have conflicting requirements for data representation. Consistency across applications is a prime consideration, and appropriate data representation is an important issue in developing practical systems for molecular biologists. Graphs are a natural representation for describing genome data, while objects are good for modeling the behavior necessary for laboratory applications. We present a method for translating graph descriptions of genome data into objects using objects as views on graphs. Graph representations describe genome concepts while objects capture individual views for application development insuring consistency across genome applications.
基因组学正成为一门数据密集型科学，越来越多的实验室正在生成的数据使传统纸质笔记本的存储不堪重负。捕获数据流需要大型系统，这些系统有多个应用程序来处理相同或相似的数据。大型系统对数据表示往往有相互冲突的要求。应用程序之间的一致性是首要考虑因素，而合适的数据表示是为分子生物学家开发实用系统时的一个重要问题。图是描述基因组数据的自然表示形式，而对象则适合对实验室应用所需的行为进行建模。我们提出了一种方法，通过将对象作为图的视图，将基因组数据的图描述转换为对象。图表示描述基因组概念，而对象捕获用于应用程序开发的各个视图，以确保基因组应用程序之间的一致性。
