耐庆大霉素金黄色葡萄球菌。在重症监护新生儿病房出现。

Gentamicin-resistant Staphylococcus aureus. Emergence in an intensive care nursery.

作者信息

Faden H, Neter E, McLaughlin S, Giacoia G

出版信息

JAMA. 1979 Jan 12;241(2):143-5.

Abstract

Gentamicin sulfate--resistant Staphylococcus aureus suddenly appeared in an intensive care nursery in December 1976 and became the dominant Staphylococcus; it accounted for 96% of the isolates by April 1977. All gentamicin-resistant strains were sensitive to amikacin sulfate, but 98% and 49% were resistant to kanamycin sulfate and tobramycin sulfate, respectively. All but one of the gentamicin-resistant strains were sensitive to methicillin sodium. The mechanism of gentamicin resistance appears to be plasmid mediated. Phage typing, used for epidemiologic purposes, also demonstrated that most gentamicin-resistant strains shared susceptibility to phages 29 and 52; however, 13% were completely different, indicating that gentamicin resistance is not solely related to a phage-susceptible factor.

摘要

1976年12月，硫酸庆大霉素耐药金黄色葡萄球菌突然出现在一家重症监护托儿所，并成为主要的葡萄球菌；到1977年4月，它占分离菌株的96%。所有耐庆大霉素菌株对硫酸阿米卡星敏感，但分别有98%和49%对硫酸卡那霉素和硫酸妥布霉素耐药。除一株耐庆大霉素菌株外，其余均对苯唑西林钠敏感。庆大霉素耐药机制似乎是由质粒介导的。用于流行病学目的的噬菌体分型也表明，大多数耐庆大霉素菌株对噬菌体29和52敏感；然而，13%的菌株完全不同，这表明庆大霉素耐药性不仅仅与噬菌体敏感因子有关。