Jialal I, Fuller C J
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052, USA.
Can J Cardiol. 1995 Oct;11 Suppl G:97G-103G.
The oxidative modification of low density lipoprotein (LDL) may be an early step in atherogenesis. Furthermore, evidence of oxidized LDL has been found in vivo. The most persuasive evidence shows that supplementation of some animal models with antioxidants slows atherosclerosis. The purpose of this review is to examine the roles that vitamin E, vitamin C and beta-carotene may play in reducing LDL oxidation.
English language articles published since 1980, particularly from groups active in this field of research.
In vitro, animal, and human studies on antioxidants, LDL oxidation, and atherosclerosis were selected.
Vitamin E has shown the most consistent effects with regard to LDL oxidation. Beta-carotene appears to have only a mild or no effect on oxidizability. Ascorbate, although it is not lipophilic, can also reduce LDL oxidative susceptibility.
LDL oxidizability can be reduced by antioxidant nutrients. However, more research is needed to establish their utility in the prevention of coronary artery disease.
低密度脂蛋白（LDL）的氧化修饰可能是动脉粥样硬化形成的早期步骤。此外，体内已发现氧化LDL的证据。最有说服力的证据表明，给一些动物模型补充抗氧化剂可减缓动脉粥样硬化。本综述的目的是探讨维生素E、维生素C和β-胡萝卜素在降低LDL氧化中可能发挥的作用。
1980年以来发表的英文文章，特别是来自该研究领域活跃团队的文章。
选择了关于抗氧化剂、LDL氧化和动脉粥样硬化的体外、动物和人体研究。
维生素E在LDL氧化方面显示出最一致的效果。β-胡萝卜素似乎对氧化能力只有轻微影响或没有影响。抗坏血酸虽然不是亲脂性的，但也能降低LDL的氧化敏感性。
抗氧化营养素可降低LDL的氧化能力。然而，需要更多的研究来确定它们在预防冠状动脉疾病中的效用。
