Anto R J, Sukumaran K, Kuttan G, Rao M N, Subbaraju V, Kuttan R
Amala Cancer Research Centre, Thrissur, Kerala, India.
Cancer Lett. 1995 Oct 20;97(1):33-7. doi: 10.1016/0304-3835(95)03945-s.
Nineteen synthetic chalcones and ten structurally related compounds were investigated for their cytotoxic, tumour reducing and antioxidant activities. Methyl and hydroxy substituted chalcones were found to be cytotoxic in vitro whereas only hydroxy substituted chalcones could reduce ascites tumour in animals. Although most of the compounds analysed showed antioxidant activity, hydroxy and methyl substituted compounds were found to be the most potent antioxidants.
对19种合成查耳酮和10种结构相关的化合物进行了细胞毒性、肿瘤抑制和抗氧化活性研究。发现甲基和羟基取代的查耳酮在体外具有细胞毒性，而只有羟基取代的查耳酮能减少动物的腹水肿瘤。虽然分析的大多数化合物都显示出抗氧化活性，但发现羟基和甲基取代的化合物是最有效的抗氧化剂。
