化学诱导的小鼠肉瘤的独特和常见肿瘤特异性移植抗原。

Unique and common tumor-specific transplantation antigens of chemically induced mouse sarcomas.

作者信息

Hellström K E, Hellström I, Brown J P

出版信息

Int J Cancer. 1978 Mar 15;21(3):317-22. doi: 10.1002/ijc.2910210311.

Abstract

Methylcholanthrene-induced sarcomas of BALB/c mice express unique tumor specific transplantation antigens (TSTA), and weaker, common TSTA. Antigens of endogenous murine leukemia virus (MuLV) expressed by some of these tumors cannot completely account for these common TSTA. However, MuLV antigens on the immunizing tumor appear to increase the immunogenicity of the common TSTA.

摘要

甲基胆蒽诱导的BALB/c小鼠肉瘤表达独特的肿瘤特异性移植抗原（TSTA）以及较弱的共同TSTA。这些肿瘤中的一些所表达的内源性鼠白血病病毒（MuLV）抗原并不能完全解释这些共同TSTA。然而，免疫肿瘤上的MuLV抗原似乎会增加共同TSTA的免疫原性。