Møller J T
Int Urol Nephrol. 1977;9(3):235-40. doi: 10.1007/BF02082169.
Of 761 fine-needle biopsy specimens obtained from the prostate by the method of Franzén, 303 originated from patients in whom either a histological diagnosis had been obtained or cancer had been confirmed by increased levels of prostatic phosphatases. Among palpable cancers, 83% were diagnosed by this method, and none of them gave falsely negative results. Among the cancers with benign palpatory findings and normal phosphatase levels, cytological examination did not show cancer in any of the cases. It is concluded that the method is unsuited for screening of proctatic cancer, but its use is indicated for the confirmation of the diagnosis in cases with abnormal palpatory findings, and when the diagnosis seems likely from the results of biochemical analysis and/or radiographic studies. On these indications, repeated aspiration should be done if the first biopsy specimen does not reveal cancer.
通过弗兰岑方法从前列腺获取的761份细针穿刺活检标本中，303份来自已获得组织学诊断或前列腺磷酸酶水平升高已确诊癌症的患者。在可触及的癌症中，83%通过该方法得以诊断，且无一例出现假阴性结果。在触诊结果为良性且磷酸酶水平正常的癌症中，细胞学检查在所有病例中均未显示癌症。结论是该方法不适用于前列腺癌筛查，但在触诊结果异常以及根据生化分析和/或影像学研究结果似乎可能确诊的病例中，可用于确诊。基于这些指征，如果首次活检标本未发现癌症，应进行重复穿刺。
