Shif M, Kempster P A
Neurosciences Department, Monash Medical Centre, Clayton, Melbourne, Victoria.
Clin Exp Neurol. 1994;31:38-42.
Twenty patients with Parkinson's disease were studied during the early phase of L-dopa treatment to clarify the development and progression of Parkinsonian motor fluctuations. Two patients had developed symptomatic motor fluctuations of moderate severity and another 3 had mild fluctuations. Both the initial response to L-dopa and the amplitude of response to a L-dopa test dose after a mean follow up period of 30 months were significantly greater for the fluctuating patients compared with those without fluctuation (p < 0.05). Although severe motor fluctuations do not usually develop until a number of years of L-dopa treatment have elapsed, this study shows that motor fluctuations can be detected quite early in the disease course and tend to appear in those patients who respond best to L-dopa.
对20例帕金森病患者在左旋多巴治疗的早期阶段进行了研究，以阐明帕金森病运动波动的发生和进展情况。2例患者出现了中度严重程度的有症状运动波动，另外3例有轻度波动。与无波动的患者相比，波动患者在平均随访30个月后对左旋多巴的初始反应以及对左旋多巴试验剂量的反应幅度均显著更大（p<0.05）。虽然严重的运动波动通常要在经过数年的左旋多巴治疗后才会出现，但本研究表明，运动波动在疾病进程中可相当早期就被检测到，并且往往出现在对左旋多巴反应最佳的患者中。
