Mohan C, Datta S K
Department of Pathology and Laboratory Medicine, University of Florida, Gainesville 32610, USA.
Clin Immunol Immunopathol. 1995 Dec;77(3):209-20. doi: 10.1006/clin.1995.1146.
The past 30 years of research on murine and human systemic lupus erythematosus has served to identify an array of immunological aberrations--some shared, some unique, some primary, others secondary-- that may underlie this disease. In integrating these findings, it appears that at least four distinct pathogenic events characterize lupus: (1) Anti-DNA Abs and immune complexes induce renal damage; (2) B-cells produce pathogenic anti-DNA antibodies; (3) Th cells drive lupus B-cells; and (4) Increased concentrations and abnormal presentation of nucleosomes. The purpose of this review is to examine the roles of these four events in the pathogenesis of lupus and to identify the different factors that can precipitate these pathogenic events.
过去30年对小鼠和人类系统性红斑狼疮的研究已用于识别一系列免疫异常——有些是共同的，有些是独特的，有些是原发性的，有些是继发性的——这些异常可能是该疾病的基础。在整合这些发现时，似乎至少有四个不同的致病事件是狼疮的特征：（1）抗DNA抗体和免疫复合物诱导肾损伤；（2）B细胞产生致病性抗DNA抗体；（3）Th细胞驱动狼疮B细胞；（4）核小体浓度增加和呈递异常。本综述的目的是研究这四个事件在狼疮发病机制中的作用，并确定可引发这些致病事件的不同因素。
