De Reuck J, Santens P, Decoo D, Crevits L, Van Maele G, Lemahieu I, Strijckmans K, Goethals P
Department of Neurology, University Hospital, Ghent, Belgium.
Clin Neurol Neurosurg. 1995 Aug;97(3):208-12. doi: 10.1016/0303-8467(95)00046-m.
Ten patients with epilepsy of unknown origin, starting after the age of 50 years, and without clear evidence of cognitive decline were studied with positron emission tomography, using the steady state technique with 15O. Cerebral blood flow and oxygen metabolism were significantly decreased in all cortical areas. No focal areas of hypometabolism were detected. Treatment with phenytoin did not influence the results. It is suggested that late-onset seizures could be the premonitory signs of a progressive encephalopathy of unknown origin.
对10例50岁以后起病、无明确认知功能减退证据的不明原因癫痫患者，采用15O稳态技术进行正电子发射断层扫描研究。所有皮质区域的脑血流量和氧代谢均显著降低。未检测到代谢减低的局灶性区域。苯妥英治疗不影响结果。提示迟发性癫痫可能是一种不明原因进行性脑病的先兆症状。
