Lecour H, Miranda A M, Nogueira J A, Abreu C
Service of Infectious Diseases, School of Medicine, Hospital de S. Joao, Porto, Portugal.
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):125-7. doi: 10.1016/0732-8893(95)00085-o.
We treated 256 children who had identified bacterial meningitis with cefotaxime. Causative organisms were: Neisseria meningitidis in 108 cases, Streptococcus pneumoniae in 61, Haemophilus influenzae in 60, enteric Gram-negative bacilli in 21, and Staphylococcus spp. in six. Daily doses of cefotaxime were 150-200 mg/kg. A total of 240 patients (93.7%) were cured. In the cured patients, sterilization of cerebrospinal fluid was obtained in the first 72 h of treatment in 214 (80.0%). Cefotaxime is an effective and safe drug for the treatment of childhood bacterial meningitis.
我们用头孢噻肟治疗了256例确诊为细菌性脑膜炎的儿童。致病微生物如下：108例为脑膜炎奈瑟菌，61例为肺炎链球菌，60例为流感嗜血杆菌，21例为肠道革兰氏阴性杆菌，6例为葡萄球菌属。头孢噻肟的日剂量为150 - 200mg/kg。共有240例患者（93.7%）治愈。在治愈的患者中，214例（80.0%）在治疗的前72小时脑脊液细菌清除。头孢噻肟是治疗儿童细菌性脑膜炎的一种有效且安全的药物。
