大剂量头孢噻肟和万古霉素治疗细菌性脑膜炎患儿脑脊液中对头孢菌素中度耐药肺炎链球菌的杀菌活性。
Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin.
作者信息
Doit C, Barre J, Cohen R, Bonacorsi S, Bourrillon A, Bingen E H
机构信息
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2050-2. doi: 10.1128/AAC.41.9.2050.
Abstract
Cerebrospinal fluid (CSF) was taken from 19 children with bacterial meningitis treated with cefotaxime (300 mg/kg of body weight/day) and vancomycin (60 mg/kg/day). Median levels of drugs in CSF were smaller than expected, as follows: 4.4 microg/ml for cefotaxime, 3.2 microg/ml for desacetylcefotaxime, and 1.7 microg/ml for vancomycin. The median CSF bactericidal titer against an intermediately cefotaxime-resistant pneumococcus was 1:4. Our data suggest at least an additive interaction between the drugs used in this study.
摘要
从19名接受头孢噻肟（300mg/kg体重/天）和万古霉素（60mg/kg/天）治疗的细菌性脑膜炎患儿中采集脑脊液（CSF）。脑脊液中药物的中位水平低于预期，具体如下：头孢噻肟为4.4μg/ml，去乙酰头孢噻肟为3.2μg/ml，万古霉素为1.7μg/ml。针对对头孢噻肟中度耐药的肺炎球菌的脑脊液杀菌效价中位数为1:4。我们的数据表明本研究中使用的药物之间至少存在相加作用。
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