Singh M M, Fähnrich M, Hasan S H, Elger W
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Contraception. 1995 Sep;52(3):187-93. doi: 10.1016/0010-7824(95)00152-z.
Ability of progesterone, gestodene, promegestone and cyproterone acetate (CPA) to reverse antigestagenic action of onapristone in adult female guinea pigs was investigated. Onapristone (10 mg/kg, s.c.) administered on post-conception days 8-11 caused resorption of implantations and vaginal bleeding in all animals. Simultaneous administration of progesterone, gestodene or promegestone on days 7-13 successfully reversed antigestagenic action of this antiprogestin, since most animals supplemented with these progestagens had viable implantations at autopsy on day 14. CPA was, however, ineffective and animals supplemented with it had only resorbed implantations and blood in uterus and vagina like that in onapristone per se treated animals. High plasma progesterone and low PGFM concentration were generally observed in all pregnant animals bearing viable implantations. PGFM (13, 14-dihydro-15-keto PGF2 alpha) was significantly elevated by day 14 in onapristone-treated (Group II) and CPA-supplemented (Group X) animals. No discernible effect on pregnancy or post-implantation embryonic development was observed in animals treated per se with these progestagens.
研究了孕酮、孕二烯酮、普美孕酮和醋酸环丙孕酮（CPA）逆转成年雌性豚鼠中孕三烯酮抗孕激素作用的能力。在受孕后第8 - 11天皮下注射孕三烯酮（10 mg/kg）会导致所有动物的着床吸收和阴道出血。在第7 - 13天同时给予孕酮、孕二烯酮或普美孕酮成功逆转了这种抗孕激素的抗孕激素作用，因为补充这些孕激素的大多数动物在第14天尸检时着床存活。然而，CPA无效，补充CPA的动物仅出现着床吸收以及子宫和阴道内有血液，类似于仅用孕三烯酮处理的动物。在所有有存活着床的妊娠动物中通常观察到高血浆孕酮和低PGFM浓度。在孕三烯酮处理组（II组）和补充CPA组（X组）动物中，到第14天PGFM（13, 14 - 二氢 - 15 - 酮PGF2α）显著升高。单独用这些孕激素处理的动物未观察到对妊娠或着床后胚胎发育有明显影响。
