Knudsen U B, Svane D, Forman A
Department of Obstetrics and Gynaecology, Aarhus University Hospital, Denmark.
J Reprod Fertil. 1998 May;113(1):75-81. doi: 10.1530/jrf.0.1130075.
Length-tension relationships and the tissue composition of the corpus and the cervix uteri were investigated in a rat model. Four groups of rats were used: nonpregnant (n = 12); day 18 of pregnancy treated with vehicle (n = 8); day 18 of pregnancy treated with the antiprogestin ZK 98 299 (Onapristone) for 19 h (n = 8); and day 22 of pregnancy during spontaneous labour (n = 8). Increased extensibility and maximal contractility in both corpus and cervix uteri were demonstrated with increased gestational age. The collagen concentration was reduced significantly in corporal preparations from pregnant rats compared with those from nonpregnant rats but not in specimens from the cervix. Antiprogestin treatment tended to increase the contractile ability.
在大鼠模型中研究了子宫体和子宫颈的长度-张力关系以及组织组成。使用了四组大鼠：未孕组（n = 12）；妊娠第18天用赋形剂处理组（n = 8）；妊娠第18天用抗孕激素ZK 98 299（奥那司酮）处理19小时组（n = 8）；妊娠第22天自然分娩组（n = 8）。随着胎龄增加，子宫体和子宫颈的伸展性和最大收缩性均增加。与未孕大鼠的子宫体标本相比，孕鼠子宫体标本中的胶原蛋白浓度显著降低，但子宫颈标本中未降低。抗孕激素处理倾向于增加收缩能力。
