通过荧光原位杂交（FISH）将人类MEN1候选基因磷脂酶C-β3（Plcb3）的小鼠同源基因定位到19B染色体区域。
Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-beta 3 (Plcb3), to chromosome region 19B by FISH.
作者信息
Gobl A E, Chowdhary B P, Shu W, Eriksson L, Larsson C, Weber G, Oberg K, Skogseid B
机构信息
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
出版信息
Cytogenet Cell Genet. 1995;71(3):257-9. doi: 10.1159/000134122.
A recent study using comparative mapping analysis suggests that the proximal segment of mouse chromosome 19 contains the mouse homologs of the human multiple endocrine neoplasia type 1 (MEN1) flanking markers proximal to the locus. We have recently shown that phospholipase C-beta 3 (PLCB3) is a candidate gene for the MEN1 syndrome. In the present investigation we used fluorescence in situ hybridization with a genomic DNA clone for mouse Plcb3, and mapped the locus to chromosome region 19B. This is in agreement with the comparative mapping of the MEN1 flanking markers in mouse.
最近一项使用比较图谱分析的研究表明，小鼠19号染色体的近端区域含有位于该位点近端的人类1型多发性内分泌肿瘤（MEN1）侧翼标记的小鼠同源物。我们最近发现磷脂酶C-β3（PLCB3）是MEN1综合征的一个候选基因。在本研究中，我们使用小鼠Plcb3的基因组DNA克隆进行荧光原位杂交，并将该基因座定位到染色体区域19B。这与小鼠中MEN1侧翼标记的比较图谱一致。
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