Wang X, Zhu C, Zhang G, Lu Y
Division of Neurosurgery, Zhujiang Hospital, First Military Medical University, Guangzhou.
Chin Med J (Engl). 1995 Aug;108(8):586-90.
Laser-Doppler flowmetry was employed in the observation of regional cortical blood flow (rCBF) after experimental subarachnoid hemorrhage (SAH) in anesthetized rats and the contents of endothelin (ET) in the cerebral-spinal fluid (CSF), plasma, hypothalamus, cerebral cortex, cerebellum and medulla were simultaneously measured. There was a biphasic change of rCBF after SAH. The contents of ET in CSF, plasma and hypothalamus rose prominently in the early stage after SAH, and the ET-increase in CSF and hypothalamus was earlier than that in plasma. The changes of ET contents in CSF correlated well with that in hypothalamus. Our results suggest that ET probably is an early important factor which induces cerebral vasospasm (CVS) after SAH. The increase of ET in CSF, which may originate from the hypothalamus, might play a more important role in the development of CVS after SAH than that in plasma.
采用激光多普勒血流仪观察麻醉大鼠实验性蛛网膜下腔出血（SAH）后局部脑皮质血流量（rCBF），并同时测定脑脊液（CSF）、血浆、下丘脑、大脑皮质、小脑和延髓中内皮素（ET）的含量。SAH后rCBF呈双相变化。SAH后早期CSF、血浆和下丘脑ET含量显著升高，CSF和下丘脑ET升高早于血浆。CSF中ET含量变化与下丘脑变化密切相关。我们的结果表明，ET可能是SAH后诱发脑血管痉挛（CVS）的早期重要因素。CSF中ET升高可能源于下丘脑，在SAH后CVS的发生发展中可能比血浆中ET升高起更重要的作用。
