Chang C J, Kao J T, Wu T J, Lu F H, Tai T Y
Department of Family Medicine, Medical College, National Taiwan University.
Diabetes Care. 1995 Aug;18(8):1191-4. doi: 10.2337/diacare.18.8.1191.
To compare serum blood lipids and lipoprotein(a) [Lp(a)] levels in Chinese non-insulin-dependent diabetes mellitus (NIDDM) patients and nondiabetic control subjects and also to determine the influence of diabetes control on serum Lp(a) concentration in Chinese individuals.
We compared the serum blood lipids and Lp(a) levels in NIDDM patients (n = 100) and age- and sex-matched nondiabetic subjects (n = 100) who participated in a case-control study. Comparisons of Lp(a) concentrations were made between a normal control group, a group of diabetic patients with HbA1c < 8.0%, and a group of diabetic patients with HbA1c of 8% or higher.
The diabetic patients had higher total triglyceride, apolipoprotein B (apo B), and apo B-to-apo AI ratios, but lower high-density lipoprotein (HDL) cholesterol and apo AI concentrations than nondiabetic controls (P < 0.001, P < 0.01, P < 0.001, P < 0.05, and P < 0.001, respectively). A similar pattern of distribution of Lp(a) levels according to the degree of metabolic control was seen in patients with NIDDM and nondiabetic controls. No correlation was observed between Lp(a) levels and total cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, apo AI, apo B, and triglyceride levels in all diabetic patients. No difference in the Lp(a) levels was noted between diabetic patients and nondiabetic subjects, even in poorly controlled diabetic patients.
In conclusion, Lp(a) levels are not elevated in diabetic patients, even in poorly controlled metabolic conditions.
比较中国非胰岛素依赖型糖尿病（NIDDM）患者与非糖尿病对照者的血脂及脂蛋白(a)[Lp(a)]水平，并确定糖尿病控制情况对中国人群血清Lp(a)浓度的影响。
我们比较了参与病例对照研究的NIDDM患者（n = 100）以及年龄和性别匹配的非糖尿病受试者（n = 100）的血脂和Lp(a)水平。对正常对照组、糖化血红蛋白（HbA1c）< 8.0%的糖尿病患者组以及HbA1c为8%或更高的糖尿病患者组的Lp(a)浓度进行了比较。
与非糖尿病对照组相比，糖尿病患者的总甘油三酯、载脂蛋白B（apo B）以及apo B与apo AI的比值更高，但高密度脂蛋白（HDL）胆固醇和apo AI浓度更低（分别为P < 0.001、P < 0.01、P < 0.001、P < 0.05和P < 0.001）。NIDDM患者和非糖尿病对照者中，根据代谢控制程度的Lp(a)水平分布模式相似。在所有糖尿病患者中，未观察到Lp(a)水平与总胆固醇、低密度脂蛋白胆固醇、HDL胆固醇、apo AI、apo B及甘油三酯水平之间存在相关性。糖尿病患者与非糖尿病受试者之间的Lp(a)水平无差异，即使是代谢控制不佳的糖尿病患者。
总之，糖尿病患者的Lp(a)水平并未升高，即使在代谢控制不佳的情况下也是如此。
